Poster 252: BMAC Augmentation of Allograft Anterior Cruciate Ligament Reconstruction Improves Patient Reported Outcomes in the Presence of Intra-articular Pathology

Objectives: A randomized control trial demonstrated evidence of earlier graft remodeling and improved 9-month International Knee Documentation Committee (IKDC) scores when anterior cruciate ligament reconstruction (ACLR) with bone-tendon-bone allograft was augmented an intra-graft injection bone marrow aspirate concentrate (BMAC). While these results are promising, the mechanism by which BMAC may affect patient reported outcome measures (PROMs) following ACLR is unclear. Methods: This a sub-analysis patients enrolled to date in IRB-approved, double-blinded, comparing undergoing BTB ± BMAC. Only who had completed at least 9 months follow-up were included. Patients stratified 1) treatment arm (BMAC versus control) 2) presence concurrent meniscus or cartilage pathology, as noted on diagnostic arthroscopy). The primary Tegner activity scale months. secondary assessed differences MRI characteristics (signal intensity ratio [SIR], volume) group. Results: final study cohort included 44 – 19 (43%) without 25 (57%) pathology 39 group - 16 (41%) 23 (59%) pathology. 24 lesion, 13 treated via meniscectomy (54%) 11 repair (46%). By comparison, 21 lesion (P=0.57), (52%, P=0.88) (P=1.00). 5 (20%) 6 (25%) injury intraoperatively (P=0.94); chondroplasty performed 2 (8.0%) 4 (16.7%). score did not differ meniscus/cartilage (P=0.816). If and/or greater mean IKDC (81.7 [SD=10.2] vs. 74.3 [SD=14.6], P=0.039). no there difference (P=0.80). Change (P=0.99) (P=0.31) groups. At 3 months, highest SIR inferior 1/3 (3.00), followed but (2.60), controls (1.95), (1.83, P=0.041). There significant volume, this comparative study. Conclusions: Amongst lesions, 8-point higher than postoperatively. However, between groups if present. Thus, amongst be mediated healing repaired tissue through undefined anti-inflammatory nociceptive pathway. Further investigation will required delineate physiologic action associated during recovery process utilized time ACL reconstruction. [Table: see text][Table: text]